Simulations Plus, a leading provider of biosimulation and performance solutions to the biopharma industry, has announced a new collaboration with the International Collaboration on Cosmetics Safety (ICCS). This partnership aims to advance animal-free science for cosmetics and other non-pharmaceutical ingredients through the use of physiologically-based kinetic (PBK) modeling approaches.
Selected through a competitive process, Simulations Plus will develop workflows for probabilistic PBK modeling of new chemicals based on pharmacokinetic (PK) analogs. The project involves reviewing data provided by ICCS, selecting target-source pairs based on similarity criteria, and building PBK models to predict exposure for target chemicals across virtual populations.
Dr. Priyata Kalra, Senior Scientist at Simulations Plus and principal investigator for the project, expressed enthusiasm about the collaboration: “Our goal is to expand the application of PBK models in animal-free safety assessments, leveraging data from ICCS to develop PBK-based read-across concepts for various chemicals and exposure routes. This partnership will establish workflows and guidance for implementing PBK modeling in these assessments.”
Dr. Maxime Le Merdy, Director of PBPK Research & Collaborations at Simulations Plus, highlighted their pioneering integration of machine learning with PBK models: “We are confident that our expertise in this area, combined with ICCS’s dedication to advancing animal-free research, will drive innovation in non-pharmaceutical markets. This research project aims to establish best practices and frameworks that will benefit companies and regulatory agencies alike.”
About Simulations Plus, Inc.
Simulations Plus has over 25 years of experience providing advanced software and consulting services to enhance drug discovery, development, and regulatory submissions in the biopharma industry. Their biosimulation solutions integrate AI/ML, PBPK, QSP/QST, and population PK/PD modeling approaches. For more information, visit www.simulations-plus.com.
About the International Collaboration on Cosmetics Safety (ICCS)
ICCS, headquartered in New York, is dedicated to promoting animal-free assessments of cosmetics and their ingredients for human health and environmental safety. The organization brings together experts from cosmetics manufacturers, research associations, and animal protection groups to advance global adoption of animal-free science through research, education, and regulatory engagement. Learn more at www.iccs-cosmetics.org.
For further details on Simulations Plus’s ESG initiatives and forward-looking statements, visit their website or read their latest updates filed with the U.S. Securities and Exchange Commission.
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